Table 6.
Functional categories of genes altered by maternal undernutrition in 12-mo-old offspring aortas as determined by DAVID bioinformatic analysis
| Function | Number of Genes | Enrichment Score | Sample Genes |
|---|---|---|---|
| Anatomic structure/ development | 74 | 5.5 | TGF beta induced transcript, CTGF, compliment component 1, NADPH oxidase 4, BMP receptor Type1A, FGF2, Angioteusin receptor 1b, clusterin, Decorin, Calpain-2 |
| Apoptosis | 18 | 2.9 | Serine/thrkinese 3, clusterin, annexinA1, apoptosis caspase activion inhibiting inhbitor, rhob gene, secreted phosphoprotein1 |
| Regulation of cell process | 59 | 2.7 | Cxxcfinger4, CTGF, Annexin A1, integrin alpha v, FGF2, Kruppel-like factor15, STAT3 |
| Cell adhesion | 20 | 2.5 | CTGF, Osteomodulin, rhob gene, integrin alpha dc and alpha1 |
| ECM-receptor | 5 | 2.3 | Synedecan4, secreted phosphoprotein1, integrin alpha5, integrin alpha v |
| Cell growth/interaction | 8 | 2.2 | CTGF PKC delta binding protein, FGF2, Diphteria toxin alpha 1 receptor |
| Receptor binding | 17 | 2.2 | TNF receptor member 11b, IL-17b, syndecan, Thrombospondin 1, Annexin A1 |
| Cell motility | 15 | 2.2 | TNF receptor member 12a, Serum response factor, STAT 3, Destrin, Vimentin, integrin alpha 1 and v |
| Cell morphogenesis | 20 | 2.1 | NADPH oxidase 4, FGF2, Clusterin, CTGF, Reticulon 4 receptor, p21 activated kinase 1 |
| Protein kinase binding | 7 | 2.1 | Syndecan4, rashomologe, PKC binding protein, Kinase interacting substance 220 |
| GAG/heparin binding | 6 | 1.9 | CTGF, FGF2, Dermatan sulphate proteoglycan 3, Thrombospondin 1 |
| ECM | 6 | 1.9 | Lumican, decorin, CTGF, osteomodulin, Thrombospondin 1, dentin matrix protein 1 |
| Phospholipid binding | 9 | 1.9 | Hyaluronidase 2, Reticulon 4 receptor, Syndecan 4 |
| Ion binding | 54 | 1.8 | Scd1, Annexin A1, cxxcfinger 4, Adenylate cyclase 5, calpain 2 |
| Vascular development/angiogenesis | 9 | 1.8 | CTGF, Serine proteinase inhibitor (clade e and f), FGF2, rhob gene, Angiotensin receptor1b, integrin alpha v, TNF receptor 12a |
| Tissue remodeling | 6 | 1.4 | CTGF, NADPH oxidase4, secreted phosphoprotein 1, TNF receptor 11b |
| Extracellular region | 40 | 1.4 | IL17b, RNAase a family 4, Prostoglandin-endoperoxide synthase1, lumican, protease serum 23, Fibulin1, proteoglycan 3 |
| Cell junction | 10 | 1.4 | Nexilin, Claudin 19, gap junction channel protein alpha 5 |
| Signal transduction | 58 | 1.2 | Cxxcfinger 4, Tensin, ADP-ribosylation factor 3, syndecan binding protein, AT1- receptor, integrin alpha d |
| Sulfotransferase | 3 | 1.1 | Heparan sulphate3-0-sulfotransferase1, Estrogen sulfotransferase, sulphotranferase family-1a |
| Serpine | 3 | 1.0 | Serine proteinase inhibitor (clade f, member 1; dade b member 6; clade e member 1) |
| Cell proliferation | 15 | 1.0 | NAPDPH oxidase 4, Clusterin, FGF2, AnnexinA1, BMP receptor1A, integrin alpa v |
| Response to stress/inflammation | 24 | 0.8 | STAT3, NADPH oxidase4, IL17B, AnnexinA1, compliment factor H, Compliment component1 |
| EGF | 3 | 0.5 | Hyaluronidose 2, Diphtoria toxin receptor, prostaglandin-endoperoxide synthase1 |
Out of 344 DAVID IDs, 142 genes could not be clustered in any category.