Table 2.

In vivo data

	Exchange Transfusion, ml/kg
	0	10	20	30	P
Hb, g/dl	13.5 ± 1.5	12.4 ± 0.8	11.8 ± 0.4	11.4 ± 0.3	*
Hematocrit, %	40.3 ± 3.3	31.8 ± 3.8	26.5 ± 1.3	23.2 ± 1.4	*
Mean alveolar Po2, Torr	141 ± 3	141 ± 6	137 ± 7	135 ± 2
Heart rate, beats/min	119 ± 5	107 ± 11	100 ± 22	106 ± 10
Pulmonary blood flow, ml · (min · kg)−1	121 ± 5	114 ± 20	119 ± 18	109 ± 10
End-expiratory lung volume, ml/kg	32 ± 5	32 ± 5	31 ± 5	31 ± 8
End-inspiratory lung volume, ml/kg	84 ± 5	84 ± 4	83 ± 5	83 ± 8
Septal tissue volume, ml/kg	5.10 ± 2.15	4.88 ± 1.84	3.80 ± 1.45	4.30 ± 1.92
DlCO, ml · (min · Torr · kg)−1	0.61 ± 0.05	0.61 ± 0.10	0.61 ± 0.06	0.60 ± 0.03
DlNO, ml · (min · Torr · kg)−1	2.69 ± 0.44	3.01 ± 0.57	3.81 ± 0.92	4.27 ± 1.08	*
	Method 1 (RF)
DmCO, ml · (min · Torr · kg)−1	1.08 ± 0.11	1.07 ± 0.23	1.21 ± 0.10	1.01 ± 0.21
Vc, ml/kg	2.75 ± 0.33	2.96 ± 0.19	2.73 ± 0.26	3.47 ± 0.64	*
	Method 2 (NO-CO, θNO = ∞)
DmCO, ml · (min · Torr · kg)−1	1.15 ± 0.19	1.29 ± 0.29	1.63 ± 0.39	1.82 ± 0.46	*†
Vc, ml/kg	2.57 ± 0.33	2.42 ± 0.22	2.18 ± 0.05	2.06 ± 0.35	*†
	Method 3 (NO-CO, θNO = 4.5)
DmCO, ml · (min · Torr · kg)−1	2.23 ± 0.70	2.68 ± 0.86	4.55 ± 2.28	4.28 ± 2.31	†
Vc, ml/kg	1.70 ± 0.25	1.66 ± 0.12	1.52 ± 0.06	1.66 ± 0.03	†

Values are means ± SD. RF, Roughton-Forster method using θ_CO from Eq. 4. NO-CO method assumes Dl_NO/Dm_CO = 2.34 and θ_NO = ∞ or θ_NO = 4.5. Repeated-measures ANOVA and post hoc Fisher's protected least significant difference:

^*P < 0.05 vs. exchange transfusion;

^†P < 0.05 vs. method 1.