Table 3.
PaO2, Torr |
V̇o2, l·min−1·Torr−1 |
||||||
---|---|---|---|---|---|---|---|
Study | Control | 6 min Hypoxia | 26 min Hypoxia | Recovery | Control | 26 min Hypoxia | Temperature, Δ°C from start to end of study |
LPBN | |||||||
Preimplant | 104 ± 11 | 30 ± 1 | 31 ± 2 | 100 ± 4 | 266 ± 17 | 547 ± 101* | 1.3 ± 0.2* |
Postimplant | 92 ± 11 | 28 ± 2 | 29 ± 1 | 93 ± 4 | 237 ± 24 | 416 ± 36* | 1.2 ± 0.2* |
Post-Atr MD | 97 ± 3 | 29 ± 1 | 28 ± 1 | 89 ± 3 | 265 ± 47 | 445 ± 59* | 0.9 ± 0.1* |
Post-IA injection | 90 ± 3 | 28 ± 1 | 27 ± 1 | 90 ± 4 | 242 ± 33 | 404 ± 49* | 1.0 ± 0.2* |
MPBN | |||||||
Preimplant | 101 ± 4 | 31 ± 1 | 28 ± 1 | 101 ± 3 | 246 ± 23 | 441 ± 81* | 0.9 ± 0.2* |
Postimplant | 92 ± 6 | 29 ± 1 | 28 ± 2 | 94 ± 5 | 241 ± 21 | 471 ± 26* | 1.6 ± 0.4* |
Post-Atr MD | 102 ± 6 | 30 ± 1 | 28 ± 2 | 98 ± 6 | 211 ± 29 | 382 ± 73* | 0.8 ± 0.3* |
Post-IA injection | 104 ± 5 | 33 ± 1 | 31 ± 2 | 104 ± 5 | 260 ± 62 | 529 ± 193* | 1.1 ± 0.2* |
KFN | |||||||
Preimplant | 97 ± 4 | 30 ± 1 | 29 ± 1 | 94 ± 2 | 246 ± 25 | 526 ± 70* | 1.1 ± 0.2* |
Postimplant | 92 ± 2 | 28 ± 1 | 29 ± 1 | 95 ± 2 | 221 ± 16 | 422 ± 50* | 1.3 ± 0.2* |
Post-Atr MD | 101 ± 3 | 31 ± 1 | 29 ± 1 | 98 ± 6 | 228 ± 19 | 234 ± 29 | 0.1 ± 0.1 |
Post-IA injection | 98 ± 5 | 31 ± 1 | 30 ± 1 | 95 ± 6 | 235 ± 12 | 278 ± 45 | 0.3 ± 0.3 |
Values are means ± SE. For all studies in every implanted group, arterial Po2 (PaO2) was uniformly decreased (P < 0.05) during hypoxia, with a return to control levels during room air recovery. In LPBN and MPBN goats during all studies and in KFN goats before and after implant of the cannula, metabolic rate (V̇o2) and body temperature during hypoxia were increased significantly (
P < 0.05) relative to control values. However in KFN goats, V̇o2 and body temperature were unchanged from control levels during hypoxia subsequent to Atr MD studies and IA injection studies.