Table 1.
Hemodynamic and morphological data in sham and CHF rats following exercise training
| Sham + Sed | Sham + ExT | CHF + Sed | CHF + ExT | |
|---|---|---|---|---|
| n | 13 | 13 | 13 | 13 |
| Body weight, g | 470 ± 5 | 438 ± 6* | 464 ± 7‡ | 449 ± 6‡ |
| Heart weight, mg | 1514 ± 27 | 1533 ± 21 | 2521 ± 50§‡ | 2443 ± 48§‡ |
| Heart weight/body weight, mg/g | 3.2 ± 0.1 | 3.5 ± 0.1 | 5.4 ± 0.1§‡ | 5.5 ± 0.1§‡ |
| Wet lung weight/body weight, mg/g | 5.3 ± 0.6 | 5.7 ± 0.5 | 9.7 ± 0.8§‡ | 9.0 ± 0.6§‡ |
| MAP, mmHg | 98.1 ± 5.7 | 95.1 ± 4.7 | 89.8 ± 4.8 | 91.5 ± 4.9 |
| HR, beats/min | 368.2 ± 8.4 | 361.0 ± 10.1 | 382.2 ± 11.5 | 377.6 ± 10.1 |
| LVEDP, mmHg | 0.8 ± 0.6 | 1.4 ± 0.8 | 14.7 ± 2.3§‡ | 14.3 ± 2.6§‡ |
| LVSP, mmHg | 126.1 ± 6.5 | 120.5 ± 5.9 | 99.2 ± 5.5*‡ | 100.2 ± 5.6*‡ |
| LVESD, mm | 3.9 ± 0.2 | 3.6 ± 0.1 | 8.0 ± 0.3§‡ | 7.6 ± 0.3§‡ |
| LVEDD, mm | 7.2 ± 0.4 | 6.9 ± 0.4 | 10.7 ± 0.3§‡ | 10.5 ± 0.3§‡ |
| LVESV, μl | 74.8 ± 4.1 | 66.1 ± 3.4 | 365.5 ± 26.8§‡ | 354.4 ± 24.6§‡ |
| LVEDV, μl | 335.8 ± 26.2 | 329.5 ± 25.6 | 608.0 ± 27.1§‡ | 599.7 ± 28.2§‡ |
| EF, % | 75.7 ± 2.8 | 77.3 ± 3.2 | 40.2 ± 2.0§‡ | 41.3 ± 2.5§‡ |
| FS, % | 45.3 ± 1.9 | 46.8 ± 2.3 | 25.2 ± 2.4§‡ | 27.1 ± 2.1§‡ |
| Infarct size, % | 0 | 0 | 42.5 ± 2.8§‡ | 41.1 ± 2.4§‡ |
| CS, μmol·g−1·min−1 | 19.3 ± 2.3 | 29.8 ± 2.9* | 12.8 ± 1.2*‡ | 19.1 ± 1.4†‡ |
Values are means ± SE; n, no. of rats. Sed, sedentary; ExT, exercise training; CHF, chronic heart failure; MAP, mean arterial pressure; HR, heart rate; LVEDP, left ventricle end-diastolic pressure; LVSP, left ventricle systolic pressure; LVESD, left ventricle end-systolic diameter; LVEDD, left ventricle end-diastolic diameter; LVESV, left ventricle end-systolic volume; LVEDV, left ventricle end-diastolic volume; EF, ejection fraction; FS, fractional shortening; CS, citrate synthase activity.
*
P < 0.05 and
§
P < 0.01 vs. sham + Sed.
†
P < 0.05 vs. CHF + Sed.
‡
P < 0.01 vs. sham + ExT.