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. 2010 Feb 18;108(5):1041–1051. doi: 10.1152/japplphysiol.01440.2009

Fig. 3.

Fig. 3.

Dilator responses of aortic rings to increasing concentrations of methacholine from mice under control conditions (open symbols: ○/☐) and following 8 wk of UCMS (filled symbols: ●/■). Data are presented under control conditions (A; control, lower bound = 10.3 ± 2.4%; UCMS, lower bound = 33.6 ± 4.4%), in response to NOS inhibition with l-NAME (B; control + l-NAME, lower bound = 84.5 ± 3.2%; UCMS + l-NAME, lower bound = 54.6 ± 5.4%), cyclooxygenase inhibition with INDO (C; control + INDO, lower bound = 21.2 ± 4.1%; UCMS + INDO, lower bound = 43.4 ± 5.2%), or both (D; control + both, lower bound = 93.4 ± 2.4%; UCMS + both, lower bound = 59.2 ± 5.6%). Data are also presented for vascular responses to increasing concentrations of sodium nitroprusside (E; control, lower bound = 2.5 ± 1.1%; UCMS, lower bound = 2.9 ± 1.3%). *P < 0.05 vs. responses in untreated vascular rings from control mice; †P < 0.05 vs. responses in untreated vascular rings from UCMS mice; n = 8–9 for control; n = 7–9 for UCMS.