Repeated melatonin treatment improves striatal function after ICH. Graphs showing the effect of repeated melatonin treatments (5 mg/kg or 15 mg/kg) given at 1, 24, 48, and 72 h after ICH, upon striatal function (forelimb placing and rotarod testing). (A) Bar graph demonstrating the effect of melatonin treatment on forelimb placing scores measured at 1–3 days and 10 weeks post-ICH. (B) Bar graph showing the change in performance on rotarod testing between baseline measurements (pre-ICH) and 8 weeks after injury (values are expressed as mean ± standard error of the mean, n = 6 per group; *p < 0.05 compared with sham animals; †p < 0.05 compared with vehicle treatment; ICH, intracerebral hemorrhage).