FIG. 5.

Repeated melatonin treatment improves cerebral histopathology 10 weeks after ICH. (A) Volume of tissue loss of the ipsilateral cerebral hemisphere. (B) Atrophy of the caudate putamen and cerebral cortex based on percentage volumetric difference between the ipsilateral and contralateral sides. (C) White-matter loss measured as percentage volumetric difference at the corpus callosum between the injured and uninjured sides. (D) The loss of neuronal density at the ipsilateral (peri-hematomal) striatum expressed as the difference in cell counts between the ipsilateral and contralateral regions (values are expressed as mean ± standard error of the mean, n = 6 per group; *p < 0.05 compared with vehicle treatment; ICH, intracerebral hemorrhage).