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. 2010 Mar 10;103(5):2532–2543. doi: 10.1152/jn.00506.2009

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Fig. 7. — I_h shortens EPSPs in afferent dendrites. A–H: whole cell current-clamp recording from afferent dendrites. Recordings were done in the presence of cAMP analogs (200 μM 8-Br-cAMP extracellularly and additionally 200 μM cAMP intracellularly). A–C: EPSP waveform before and while blocking I_h with 2 mM CsCl. A: average EPSP waveform before (black) and during application of 2 mM CsCl (red). B: EPSP decay time constants (τ_decay) plotted against EPSP amplitudes before and while blocking I_h with 2 mM CsCl; control: τ_decay = 4.97 ms (black, 34 EPSPs); in 2 mM CsCl: τ_decay = 7.18 ms (red, 41 EPSPs). C: summarized results from 7 recordings. D–F: EPSP waveform before and during application of 50 μM ZD7288. D: average EPSP waveform before (black) and during application of 50 μM ZD7288 (magenta). E: EPSP decay time constants (τ_decay) plotted against EPSP amplitudes; control: τ_decay = 5.38 ms (black, 22 EPSPs), in 50 μM ZD7288: τ_decay = 8.30 ms (magenta, 16 EPSPs). F: summarized results from 6 recordings.