Table 2.
Differences in lwDR membrane characteristics remain despite blockade of major synaptic input
| RMP, mV | Res, MOhm | Tau, ms | AP Thr, mV | AP Amp, mV | AP Dur, ms | AHP Amp, mV | AHP t1/2, ms | Firing Rate @80 pA, Hz | Gain, Hz/pA | |
|---|---|---|---|---|---|---|---|---|---|---|
| vmDR | −66.1 ± 4.8 | 441.5 ± 49.2 | 22.8 ± 4.5 | −21.4 ± 1.3 | 59.5 ± 2.2 | 1.9 ± 0.1 | 27.2 ± 1.8 | 134.1 ± 41.7 | 2.1 ± 0.8 | 0.03 ± 0.01 |
| lwDR | −60.6 ± 4.6 | 667.2 ± 34.2** | 37.2 ± 3.5* | −24.8 ± 1.3 | 67.4 ± 2.7* | 3.0 ± 0.2*** | 29.8 ± 1.3 | 259.4 ± 15.5* | 6.7 ± 1.7* | 0.09 ± 0.02* |
Values are means ± SE; vmDR, n = 5; lwDR, n = 6.
*
P < 0.05;
**
P < 0.01;
***
P < 0.001. Student's t-test was used to compare attributes of vmDR neurons versus lwDR neurons following pharmacological blockade of major synaptic input to 5-HT neurons. See Table 1 for abbreviations.