Fig. 5.

Structural organization of the functional dimer and overall structures of KATs. Functional dimers (top) and different domains of a monomer (bottom) of human KAT I (a), human KAT II (b), mouse KAT III (c), and mouse KAT IV (d). The two subunits are differently colored in each image. The small and large domains are depicted in blue and green, respectively; the N-terminal arms or N-terminal parts are in pink. The PLP cofactor is depicted with sticks. The box in B indicates the two two-stranded β-sheets that provide a major contribution to dimer stability in human KAT II. Figures were generated with PyMOL [137]