Fig. 7.

Conformational changes of KATs during catalysis. The structures of free (magenta) and ligand-bound (cyan) forms of each KAT structure are superposed upon each other. a Human KAT I, b human KAT II, c mouse KAT III. The N-terminal α-helices are shown as ribbons and the other residues that show significant side chain repositioning are depicted as sticks. Residues with an asterisk are from the secondary subunit in each functional dimer. The arrows show the direction of the movement the N-terminal α-helices and some crucial residues upon ligand binding