Table 1.

Altered CNS (cerebrospinal fluid/brain tissue) KYNA levels in selected disease states

Disease state	KYNA	Reference
Alzheimer’s	↓	[8, 9]
Parkinson’s	↓	[10]
Multiple sclerosis	↓	[11]
Huntington’s	↓	[8, 12–14]
Neonatal asphyxia	↓	[15, 16]
Cerebral malaria	↑	[17]
HIV infection	↑	[8, 18]
Down’s syndrome	↑	[19]
Amyotrophic lateral sclerosis	↑	[20]
Schizophrenia	↑	[21–23]
Epilepsy	↑	[24]