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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Neuropharmacology. 2010 Mar 6;58(8):1199–1205. doi: 10.1016/j.neuropharm.2010.02.015

Figure 3. Baseline activity, saline- and d-amphetamine-induced locomotor activity in wild type, NTS1−/−, and NTS2−/− mice.

Figure 3

Activity was recorded in a plexiglass Opto-Varimax Minor activity chamber (Colombus Instruments, Colombus. OH). The mice (n=4–13) were acclimated to the activity chamber for 2h after which baseline activity was recorded for 1h. The mice were then injected with saline and 30min later with saline or d-amphetamine (4 mg/kg i.p.). Activity was recorded for 2h post the last injection. Inset shoes the time course for the baseline. Data is presented as mean ± SEM. P<0.05 is considered significant.

*significantly different from WT; $significantly different from NTS2−/−; #significantly different saline treated animals in the same genotype.

AMP= d-amphetamine

WT=wild type

NTS1−/− =NTS1 knockout mice

NTS2−/− =NTS2 knockout mice

S=saline

A=d-amphetamine