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. Author manuscript; available in PMC: 2010 May 11.
Published in final edited form as: Annu Rev Genet. 2008;42:335–359. doi: 10.1146/annurev.genet.42.110807.091620

Figure 4.

Figure 4

A schematic representation of the interface between kinetochore microtubule, kinetochore and pericentric chromatin. The microtubule ( green, right) is a 25-nm tubule comprised of 13 protofilaments. Pericentric chromatin (blue nucleosomes and red DNA) is organized into an intramolecular loop in mitosis. The dimensions of a single nucleosome are 5 × 11.5 nm. The dimension of an intramolecular loop would be approximately 23 nm. The two major polymers (nucleosomal DNA and microtubules) are similar in cross-sectional dimension. The kinetochore is a proteinaceous structure linking these two polymers in mitosis.