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. Author manuscript; available in PMC: 2010 May 11.
Published in final edited form as: Annu Rev Genet. 2008;42:335–359. doi: 10.1146/annurev.genet.42.110807.091620

Figure 5.

Figure 5

Is the yeast spindle comparable to one mammalian kinetochore? (a) The segregation apparatus in budding yeast is composed of kinetochore and interpolar microtubules ( green) and pericentric chromatin organized into C-loops of intramolecularly paired chromatids (136). Sister centromeres are separated by an average of 800 nm in mitosis (97), and are clustered into a single diffraction-limited spot in mitosis. (b) Longitudinal section through a HeLa cell in prometaphase (109a). The trilaminar structure of a mammalian kinetochore is marked by the orange and red dots. Multiple attachment sites may be clustered whether they are on separate chromosomes (as in budding yeast) or within a single chromosome (as in the Hela cell shown here).