Table 1.
Baseline characterization of ADNI 1 cohorts.
| Characteristic | Controls (n = 229) | MCI (n = 398) | Mild AD (n = 192) |
|---|---|---|---|
| Age, mean ± SD, y | 75.8±5.0 | 74.7±7.4 | 75.3±7.5 |
| Education, mean ± SD, y | 16.0±2.9 | 15.7±3.0 | 14.7±3.1 |
| Sex (% Female) | 48.0 | 35.4 | 47.4 |
| Apolipoprotein E €4, % carriers | 26.6 | 53.3 | 66.1 |
| MMSE Score | 29.1± 1.0 | 27.0± 1.8 | 23.3± 2.1 |
| CDR Global Score | 0.0± 0.0 | 0.5± 0.0 | 0.7± 0.3 |
| CDR Sum of Boxes | 0.0± 0.1 | 1.6± 0.9 | 4.3± 1.6 |
| GDS Score | 0.8± 1.1 | 1.6± 1.4 | 1.7± 1.4 |
| ADCS MCI-ADL (FAQ) Score | 0.1± 0.6 | 3.9± 4.5 | 13.0± 6.9 |
| ADAS-Cog total | 6.2± 2.9 | 11.5± 4.4 | 18.6± 6.3 |
| ADAS word list delayed recall | 2.9± 1.7 | 6.2± 2.3 | 8.6± 1.6 |
| AVLT Trials 1-5 | 43.3± 9.1 | 30.7± 9.0 | 23.2± 7.7 |
| AVLT delayed recall | 7.4± 3.7 | 2.8± 3.3 | 0.7± 1.6 |
| AVLT DR/Trial 5 % | 65.8±27.6 | 32.1±31.3 | 11.2±22.0 |
| Trails A (seconds) | 36.5±13.2 | 44.9±22.8 | 68.0±36.9 |
| Trails B (seconds) | 89.2±44.3 | 130.7±73.5 | 198.9±87.2 |
| Category fluency (animal) | 19.9± 5.6 | 15.9± 4.9 | 12.4± 4.9 |
| Category fluency (vegetable) | 14.7± 3.9 | 10.7± 3.5 | 7.8± 3.3 |
| Number cancellation* | 0.4± 0.7 | 1.0± 0.9 | 1.8± 1.3 |
| Boston naming test | 27.9± 2.3 | 25.5± 4.1 | 22.4± 6.2 |
| Digits backwards | 7.2± 2.2 | 6.2± 2.0 | 5.0± 1.8 |
| Clock drawing | 4.7± 0.7 | 4.2± 1.0 | 3.4± 1.3 |