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. Author manuscript; available in PMC: 2011 May 7.
Published in final edited form as: Cell Stem Cell. 2010 May 7;6(5):479–491. doi: 10.1016/j.stem.2010.03.018

Figure 3. Expansion of Distinct Chromatin Blocks Marks Developmental Genes.

Figure 3

(A) The number of promoters marked by various combinations of chromatin modifications in hESC (black) and IMR90 (white). Exact combinations including H3K4me3, can be found for RefSeq genes in Supplemental Table S7. Abbreviations: K4, H3K4me3; K9, H3K9me3; K27, H3K27me3; none, lacking K4/K9/K27. (B–C) Snapshots of domains and chromatin structure around promoters which gain H3K9me3 and H3K27me3 in IMR90, for (B) GPC3, (C) POU3F4, and (D) PAX3. (E) Gene Ontology - biological processes enriched in promoters that are marked by both H3K9me3 and H3K27me3 in IMR90, along with (F) examples of developmentally relevant genes having this chromatin structure.