Table 1.

Distribution of genotype frequencies for FcγRIIb^T232 in controls and severe malarial cohorts of Kenyan children

	Malarial control group 1 (n = 998)		Severe malaria case group 1 (n = 684)			Control group 2 (n = 1,706)		Severe malaria case group 2 (n = 731)			Combined
	n	Frequency	n	Frequency	P value	n	Frequency	n	Frequency	P value	P value
II	475	0.476	345	0.504		875	0.513	391	0.534
TT	87	0.087	31	0.045	4.1 × 10−3*†	125	0.073	34	0.047	0.048*
IT	436	0.436	308	0.450		706	0.414	306	0.419
TT	87	0.087	31	0.0453	1.0 × 10−3‡	125	0.073	34	0.047	0.019‡	7.1 × 10−5§
IT and II	911	0.913	653	0.955	OR = 0.50	1,581	0.927	696	0.953	OR = 0.62	OR = 0.56
					(0.33–0.76)					(0.42–0.91)	(0.42–0.74)

II denotes individuals homozygous for FcγRIIb^I232, TT denotes individuals homozygous for FcγRIIb^T232, and IT denotes heterozygotes.

*P value was calculated by χ² test using 2 × 3 contingency table (df = 2).

^†Genotype was not associated with specific features of severe malaria, including hematocrit, parasitemia, conscious level, or respiratory symptoms (multiple logistic regression) (Table S8).

^‡P value and OR calculated by χ² test using 2 × 2 contingency table (df = 1). Numbers in parentheses refer to 95% confidence intervals.

^§Combined P value from meta-analysis of the two cohorts using StatsDirect software.