Table 2.

Metabolic balance data in Cldn2^+/+ and Cldn2^−/− mice

	+/+	−/−
No. of animals	10	10
BW, g	28.2 ± 0.7	28.4 ± 0.4
Water intake, μL/24 h per gram BW	200.1 ± 28.0	248.8 ± 31.5
Food intake, μg/24 h per gram BW	155.8 ± 21.2	176.8 ± 16.7
Urine volune, μL/24 h per gram BW	58.1 ± 6.8	100.8 ± 17.9*
FENa, %	0.28 ± 0.03	0.32 ± 0.02
FEK, %	25.9 ± 3.9	24.6 ± 2.1
FECl, %	0.63 ± 0.07	0.58 ± 0.05
FEMg, %	4.5 ± 0.5	4.8 ± 0.7
FECa, %	0.13 ± 0.01	0.40 ± 0.04**
FEP, %	9.2 ± 1.0	11.5 ± 1.1
Urine glucose, mg/mg cr	1.43 ± 0.12	1.48 ± 0.34
Urine albumin, μg/mg cr	7.6 ± 1.4	7.1 ± 1.2
Urine osmolality, mOsm/kgH2O	2,499.1 ± 128.6	2,000.4 ± 125.4*
Ccr, mL/24 h per gram BW	21.5 ± 2.1	23.3 ± 1.7

Values are mean ± SEM. BW, body weight; Ccr, creatinine clearance; FE, fractional excretion.

*P < 0.05, **P < 0.001 vs. Cldn2^+/+ mice.