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LAG-3+CD8+ T cells in TALs and TILs exhibit high PD-1 expression. (A and B) The expression of PD-1 and CD127 on whole CD8+ or LAG-3+CD8+ cells in PBLs, TALs, or TILs. *P < 0.05 compared with whole CD8+ cells of healthy donors’ (HD) PBLs. #P < 0.05 compared with whole CD8+ cells of each corresponding tissue. (C) IFN-γ and TNF-α production from each indicated population following stimulation with PMA/ionomycin. The result shown is representative of samples from three patients.
