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Ovarian tumor ascites induce PD-1 and LAG-3 expression on CD8+ T cells. (A) PBLs from healthy donor were cultured in tumor ascites. PD-1 and LAG-3 expression were analyzed on CD8+ cells. (B and C) At 4 days of culture in ascites, multicytokine production from CD8+ cells was evaluated following stimulation with PMA/ionomycin. The relationship between surface PD-1 and LAG-3 expression and multicytokine-producing CD8+ T cells cultured in ascites derived from 17 patients is represented.
