Table 4.

Percentage change in the aerobic and anaerobic steady states of dependent variables X₁ (mRNA), X₂ (inactive FNR), and X₃ (active FNR) in response to variation in the parameters that define the system

	Sensitivities
	Aerobic			Anaerobic
Parameter	X1	X2	X3	X1	X2	X3
α1,max/α1	1	0.95±0.004	1.9±0.0081	0.68±0.011	0.35±0.0055	0.69±0.011
α21	0	0.95±0.004	1.9±0.0081	−0.32±0.011	0.35±0.0055	0.69±0.011
α22	0	0.045±0.004	−0.91±0.0081	0a	0a	0a
β1,off/β1,on	−1	−0.95±0.004	−1.9±0.0081	−0.68±0.011	−0.35±0.0055	−0.69±0.011
β21,off/β21,on	0	−0.91±0.0081	−1.8±0.016	0.011±0.0011	−0.012±0.0011	−0.024±0.0021
β22	0	−0.045±0.004	0.91±0.0081	−0.0055±0.0005	−0.49±0.0005	0.012±0.0011
β31,off/β31,on	0	−0.045±0.004	−0.091±0.0081	0.31±0.011	0.16±0.0055	−0.68±0.011
g13	—b	—b	—b	−0.18±0.015	−0.091±0.0074	−0.18±0.015

The parameters are as follows: α_1,max/α₁ (transcription rate), α₂₁ (translation rate), α₂₂ (rate of disassociation of active FNR dimer), β_1,off/β_1,on (rate of mRNA degradation), β_21,off/β_21,on (rate of degradation of inactive FNR monomer), β₂₂ (rate of dimerization), β_31,off/β_31,on (rate of degradation of active FNR dimer), and g₁₃ (kinetic order of repression of mRNA synthesis). The mean and standard deviation for the sensitivities are computed with respect to the parameter sets that define the confidence intervals.

^aThe relevant flux for α₂₂ is not present in the fully anaerobic state.

^bg₁₃ is not defined for the aerobic state.