Table 3.
Complete set of historical TSE cases in small ruminants identified in Switzerland.
| Surveillance stream | Case ID | Year of Diagnosis | Species | Age (years) |
Sex | PRNP Genotype |
Primary diagnosis | Tested flock mates |
|---|---|---|---|---|---|---|---|---|
| - | 15355 | 1981 | goat | 3 | f | nd | scrapie1 | - |
| passive | 21658 | 1991 | sheep | 4 | f | nd | scrapie1 | 18 |
| 22614 | 1993 | goat | 2 | f | nd | scrapie1 | 25 | |
| 22805 | 1993 | sheep | > 1.5 | nr | nd | scrapie1 | 17 | |
| 22856 | 1993 | sheep | 6 | f | nd | scrapie1 | 3 | |
| 24058 | 1995 | sheep | 1.5 | f | nd | scrapie1 | 11 | |
| 30842 | 1999 | sheep | 3.5 | m | VRQ/VRQ | scrapie2 | 19 | |
| S7/CS | 2004 | sheep | 6 | f | ARQ/ARQ | atypical scrapie3 | 31 | |
| active | G1/RS | 2004 | goat | 10 | f | AHQ/AHQ | atypical scrapie3 | 17 |
| G2/FS | 2004 | goat | 12 | m | AHQ/AHQ | atypical scrapie3 | 1 | |
| S1/RS | 2004 | sheep | nr | f | VRQ/VRQ | classical scrapie3 | 42 | |
| S2/RS | 2004 | sheep | nr | f | ARR/ARR | atypical scrapie3 | 169 | |
| S3/RS | 2004 | sheep | nr | f | ARR/ARR | atypical scrapie3 | 3 | |
| S4/RS | 2004 | sheep | 10 | f | AHQ/AHQ | atypical scrapie3 | - | |
| S5/FS | 2004 | sheep | 6 | f | AHQ/ARQ | atypical scrapie3 | 30 | |
| S6/FS | 2005 | sheep | > 1.5 | f | ARR/ARR | atypical scrapie3 | 16 | |
The primary diagnosis was established by state-of-the-art techniques at the year of confirmation and for cases identified before 2004 involved no means to discriminate BSE and atypical scrapie from classical scrapie.
1confimed by histopathology
2confimed by histopathology and immunohistochemistry
3confirmed by immunohistochemistry and subjected to biochemical TSE typing by Western immunoblot in a previous study [24].
G, goat; S, sheep; RS, regularly slaughtered; FS, fallen stock; CS, clinical suspect; nd, not done; nr, not reported; f, female; m, male