Table 2.
Methodological quality of included trials. Numbers represent quality score values
|
Randomisation*
|
Blinding
|
Withdrawal/dropout
|
Quality score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Method not described | Appropriate method | No blinding reported | Double blind; means not reported | Double blind; means appropriate | Not described | Described | ||||
| Single dose protocol | ||||||||||
| Ducharme et al (unpublished) | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Schuh et al19 | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Beck et al32 | 1 | — | — | — | 2 | 0 | — | 3 | ||
| Phanichyakam et al33 | 1 | — | 0 | — | — | 0 | — | 1 | ||
| Cook et al15 | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Multiple dose strict protocol | ||||||||||
| Qureshi et al20 | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Reisman et al16 | 1 | — | — | — | 2 | 0 | — | 3 | ||
| Schuh et al19 | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Watson et al17 | 1 | — | — | 1 | — | — | 1 | 3 | ||
| Peterson et al (unpublished) | — | 2 | — | — | 2 | — | 1 | 5† | ||
| Multiple dose flexible protocol | ||||||||||
| Guill et al14 | — | 2 | — | — | 2 | — | 1 | 5† | ||
*
All trials scored 0 for non-reported randomisation.
†
Methodology confirmed by authors.