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. 2010 May 11;5(5):e10583. doi: 10.1371/journal.pone.0010583

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Five B6 mice per group were primed intranasally as described in figure 1. Mock-primed (A) or Memphis virus-primed (B) animals were depleted of either CD8- or CD4 T cell subset in vivo as described in Materials and Methods. Monitoring of body weight loss after lethal challenge with Taiwan virus and expression of the results were described in detail in figure 1. One representative result is shown from two independent studies with similar results. Asterisk (*) indicates a statistically significant difference when CD8-depleted group was compared with PBS control group.