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. 2010 May 11;5(5):e10565. doi: 10.1371/journal.pone.0010565

Table 2. Frequency of Microphthalmia and/or Coloboma with 6 ng MO1 Morpholino and 100 pg human TMX3 wild type or 100 pg of human TMX3/(p.Arg39Gln).

MO1 Morpholino (n = 349) MO1 Morpholino +100 pg Human TMX3 wild type (n = 582) MO1 Morpholino +100 pg Human TMX3/(p.Arg39Gln) (n = 440)
Microphthalmia/Colobomaa 18 (5.2%) 7 (1.2%)c 30 (6.8%)d
External Toxicityb 46 (13.2%) 164 (28.18%) 77 (17.5%)
Normal 285 (81.6%) 411 (70.62%) 333 (75.7%)

Microphthalmia/Colobomaa: Larvae with microphthalmia or coloboma only and without any other evidence external toxicity.

External toxicityb: Edema, body axis curving; can also include eye defects.

c

: P = 0.0031 for the frequency of microphthalmia and/or coloboma using MO1 morpholino versus frequency of microphthalmia and/or coloboma using MO1 morpholino +100 pg Human TMX3 wild type. Fish with external toxicity were excluded from the analysis. A two-tailed Fisher's exact test was used.

d

: P = 0.293 for the frequency of microphthalmia and/or coloboma using MO1 morpholino versus frequency of microphthalmia and/or coloboma using MO1 morpholino +100 pg Human TMX3(p.Arg39Gln). Fish with external toxicity were excluded from the analysis. A two-tailed Fisher's exact test was used.