Table 4.
Possible associations between p16INK4A expression and clinicopathological parameters of colon cancer
| p16 expression | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| neg | % | weak | % | mod | % | strong | % | P | ||
| HPV | - | 14 | 60.9 | 10 | 90.9 | 12 | 66.7 | 24 | 63.2 | 0.325 |
| + | 9 | 39.1 | 1 | 9.1 | 6 | 33.3 | 14 | 36.8 | ||
| MSI | MSS | 19 | 86.4 | 11 | 100.0 | 17 | 94.4 | 37 | 97.4 | 0.266 |
| MSI | 3 | 22.6 | 0 | 0.0 | 1 | 5.6 | 1 | 2.6 | ||
| age (median) | 63 | 70 | 66 | 65 | 0.344 | |||||
| gender | male | 10 | 43.5 | 7 | 63.6 | 12 | 66.7 | 21 | 55.3 | 0.466 |
| female | 13 | 56.5 | 4 | 36.4 | 6 | 33.3 | 17 | 44.7 | ||
| lymph nodes | - | 9 | 60.0 | 6 | 66.7 | 6 | 66.7 | 24 | 68.6 | 0.951 |
| + | 6 | 40.0 | 3 | 33.3 | 12 | 33.3 | 11 | 31.4 | ||
| grade of differentiation | good | 12 | 54.5 | 7 | 63.6 | 8 | 44.4 | 18 | 51.4 | 0.875 |
| moderate | 7 | 31.8 | 3 | 27.3 | 9 | 50.0 | 13 | 37.1 | ||
| poor | 3 | 13.6 | 1 | 9.1 | 1 | 6.6 | 4 | 11.4 | ||
| location | proximal | 16 | 69.6 | 2 | 18.2 | 4 | 22.2 | 8 | 22.2 | 0.002 |
| distal | 2 | 8.7 | 3 | 27.3 | 9 | 50.0 | 16 | 44.4 | ||
| rectum | 5 | 21.7 | 6 | 54.5 | 5 | 27.8 | 12 | 33.3 | ||
| stage | I | 3 | 13.0 | 4 | 40.0 | 2 | 11.8 | 4 | 10.8 | 0.066 |
| II | 8 | 34.8 | 2 | 20.0 | 4 | 23.5 | 18 | 48.6 | ||
| III | 10 | 43.5 | 4 | 40.0 | 6 | 35.3 | 13 | 35.1 | ||
| IV | 2 | 8.7 | 0 | 0.0 | 5 | 29.4 | 2 | 5.4 | ||
| adjuvant therapy | no | 6 | 30.0 | 6 | 75.0 | 5 | 33.3 | 15 | 55.6 | 0.186 |
| yes | 14 | 70.0 | 2 | 25.0 | 10 | 66.7 | 12 | 44.4 | ||
Possible associations were investigated using the χ2-test or Fisher's exact test (when appropriate) for categorical variables and using Student t-test or Mann-Whitney U test (when appropriate) for continuous variables (MSI: microsatellite instability, MSS: microsatellite stability).