Table 2.

Effect of major depression (MDD) on various measures in the PFC of subjects in the suicide group^a

Variables		Normal controls (n=21) 1		Subjects in the suicide group (n=28)				Overall ANOVA			P value for Multiple comparison by groupb
				With a history of MDD (n=11) 2		With a history of other psychiatric disorders (n=17) 3
		Mean	SD	Mean	SD	Mean	SD	df	F	P	1 vs 2	1 vs 3	2 vs 3
Akt1 studies
Akt1 catalytic activityb Immunolabelingb		100	15	55	16	59	15	2,46	44.78	<.001	<.001	<.001	.49
p-Akt1 (Thr308)		100	11	59	19	65	17	2,46	36.89	<.001	<.001	<.001	.23
p-Akt1 (Ser473)		100	13	63	18	59	13	2,46	46.29	<.001	<.001	<.001	.41
PDK1 studies
Catalytic activityb		100	19	68	10	62	14	2,46	32.32	<.001	<.001	<.001	.29
p-PDK1 immunolabelingb		100	17	73	24	69	13	2,46	16.19	<.001	<.001	<.001	.58
PTEN studies
mRNAc		495	82	932	131	958	177	2,46	69.85	<.001	<.001	<.001	.61
Total PTEN immunolabelingb		100	19	145	26	139	33	2,46	15.33	<.001	<.001	<.001	.60
p-PTENd
		1.02	.22	.72	.12	.71	.21	2,46	14.53	<.001	<.001	<.001	.89

^aData were analyzed using univariate analysis of variance (ANOVA). Bonferroni-adjusted P values were considered significant (P = .05/7 = .007).

^bGroup 1 indicates normal controls; group 2, subjects in the suicide group with a history of MDD; and group 3, subjects in the suicide group with a history of other psychiatric disorders. ^bPercent of control;

^cattomoles/µg total RNA;

^dratio to total PTEN