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SLAM family receptors in the immune synapse. The mostly homophilic interactions between SLAMF receptors subserve their role as costimulatory molecules. The binding of the SLAMF receptors to their ligands induces tyrosine phosphorylation of ITSM motifs in their cytoplasmic tail to which the adapters SAP or EAT-2 bind subsequently. SAP is mostly expressed by T cells, whereas EAT-2 is primarily expressed in APC
