Fig. 2.

Cytoplasmic tails of human SLAM receptors and the functional ITSM motifs and other docking sites. Cytoplasmic tails of human full-length SLAMF1 and SLAMF3-7 contain several ITSM motifs (tyrosine (Y) in red) which are docking sites for the SAP and EAT-2 adapters. Additional tyrosines are in the cytoplasmic tail of the SLAMF molecules (Y in black) are involved in the association with other effector molecules, e.g., SLAMF3 binds to the adaptor molecules AP-2 and Grb-2. Numbers indicate the tyrosine position relative to the molecule's N-terminal amino acid accession numbers between brackets correspond to Ensembl ID