Fig. 4.

Signal transduction by SLAM family surface receptors in CD4+ T cells. During formation of the immune synapse, clustering of SLAMF receptors brings SAP to its cytoplasmic tails and mediates recruitment and activation of Fyn. Thus, SLAMF receptors modulate TCR signaling by inducing a sustained recruitment of PKCθ and Bcl-10, which in turn leads to the activation of NF-κB and consequently to the production of Th2 cytokines and participation in NKT/innate CD4 T cell development. Phosphorylated tyrosines in the SLAMF cytoplasmic tails triggers the association with SHIP, docking protein 1 (DOK1), DOK2, and RAS-GAP, which may participate in these processes