Figure 5.

Oligo- to multi-focal atrophy of cardiac muscle is evident in animals lacking both AT₁ subtypes (−/−//−/−//+/+ and −/−//−/−//−/−) and angiotensinogen-deficient (Agt −/−) mice, whereas animals lacking none or only one AT₁-subtype (exemplarily shown +/+//+/+//+/+ and −/−//+/+//+/+). Arrows indicate dense reticular network, partially collapsed, with individualized muscle fibres, and occasional angular outline, as well as loss of muscle fibres (HE-stained; magnification: 400-fold representative sections for all groups from n ≥ 4 sections).