Figure 3.

Light photomicrograph of colon tissues from TNBS-induced colitis rats. In control rats, normal histological colon morphology is evident (A, × 4). At day 3, oedema and haemorrhage at the mucosa with goblet cell depletion were seen (B, × 20). At day 7, severe transmural infiltration of the colon wall developed, with submucosal oedema and haemorrhage, lymphocytic and neutrophilic infiltration (M) and coagulative necrosis (C, × 10). At day 14, goblet cell regeneration (N), oedema and haemorrhage regressed by degrees (D, × 20). At day 21, abundant goblet cells and crypts developed (E, × 10). At day 28, oedema and haemorrhage had almost entirely disappeared, the structure of the muscular layer became compact and the intestinal glands developed highly (F, × 4).