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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: J Immunol. 2010 Mar 10;184(8):4196–4204. doi: 10.4049/jimmunol.0903931

Figure 5.

Figure 5

NRP-V7+CD8+ T cells that express TRBV 13-3 accumulate in the islets and are deleted by Kd-NRP-V7-SAP. T cells were isolated from the islets of NOD mice 3 weeks post-initial treatment with Kd-NRP-V7-SAP, 3 weeks post-treatment with PBS, or from the islets, PLN, and spleen of unmanipulated NOD mice 8–14 weeks of age. Each data point represents proportion of islet-infiltrating NRP-V7+CD8+ T cells from a single mouse that expressed TRBV 13-3. One mouse from the Kd-NRP-V7-SAP treated group and one mouse from the PBS group had less than 2 CD8+ T cells per islet (less than 5% of the average number) and only one tetramer-positive T cell in the sample. These mice were considered to have not developed insulitis and were excluded from this analysis. Data were analyzed using the Kruskal-Wallis test with Dunn’s post-tests. Significant differences were found between the Kd-NRP-V7-SAP and PBS treated NOD mice (P < 0.05), 8–10 week islets (P < 0.01), and 12–14 week islets (P < 0.001).