Table 2.

Patterns in overlap between autism-associated genes and alleles and schizophrenia-associated genes and alleles

Autism and schizophrenia
Shared alleles	Different alleles	Different markers	Complex overlap	Autism, not schiz.	Schiz., not autism	Not autism, not schiz.
DAO†	AHI1†	BDNF	CNTNAP2†	NRCAM†	CTLA4	CYP21A2
DISC1†	APOE	DRD3†	COMT†	SLC25A12	DAOA	DBH
GRIK2	DRD1	EGF	NRXN1†		DRD2	DDC
GSTM1†	FOXP2†	NTNG1†	SLC6A4†		DRD4	GABRA5
MTHFR†	HLA-DRB1	RELN†			HTR2A	GABRG2
	SHANK3†				HTR7	GABRP
					NOTCH4	GSTP1
					NRG1	PENK
					SLC6A3	RYR3
					TH	SYNGAP1
					TPH1	TYR
						YWHAB

Bold genes are included in the list of top 30 SZgene candidates (http://www.schizophreniaforum.org/res/sczgene/default.asp), as determined by effect size.

^†At least one of the studies of autism showing positive associations used diagnostic criteria of “autism spectrum,” “autistic spectrum,” PDD-NOS, or “broad spectrum” autism, as compared to just “autism.”