Table 4.
Association of hTERT common alleles/genotypes with exceptional longevity
| Nature of variation | Controls (n = 49) | Centenarians (n = 73) | P value† | |||
| Allele, % | ||||||
| TERT | Exon 1 | IVS1–187 T > C | C | 36.7 | 42.5 | 0.3717 |
| Exon 2 | 973 G > A (A 305 A) | A | 30.6 | 34.9 | 0.4834 | |
| Exon 14 | 3097 C > T (H 1013 H) | T | 8.1 | 21.9 | 0.0049 | |
| Exon 16 | IVS16+99 C > T | T | 11.2 | 16.4 | 0.2556 | |
| TERC | IVS+63 T > C | C | 18.5 | 18.8 | 0.9402 | |
| Genotype, % | ||||||
| TERT | Exon 1 | IVS1–187 T > C | TT | 40.8 | 31.5 | 0.4494 |
| CT | 44.9 | 52.1 | ||||
| CC | 14.3 | 16.4 | ||||
| Exon 2 | 973 G > A (A 305 A) | GG | 53.1 | 43.8 | 0.5313 | |
| GA | 32.7 | 42.5 | ||||
| AA | 14.3 | 13.7 | ||||
| Exon 14 | 3097 C > T (H 1013 H) | CC | 85.7 | 63.9 | 0.035 | |
| CT | 12.2 | 26.8 | ||||
| TT | 2 | 8.5 | ||||
| Exon 16 | IVS16+99 C > T | CC | 81.6 | 68.5 | 0.0972 | |
| CT | 14.3 | 30.1 | ||||
| TT | 4.1 | 1.4 | ||||
| TERC | IVS+63 T > C | TT | 64.4 | 66.2 | 0.5653 | |
| CT | 34.2 | 29.9 | ||||
| CC | 1.4 | 3.9 | ||||
†Adjusted for age and gender.