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VMRs are often located near T-DMRs. Shown are mouse Ptp4a1, a protein tyrosine phosphatase involved in maintaining differentiated epithelial tissues (A), and human FOXD2, a forkhead transcription factor involved in embryogenesis (B). Labeling is as in Fig. 1. In (A), the VMR and T-DMR coincide, whereas in (B), they are adjacent.
