Table 1. Main Effects of Session, Cue, and Their Interactions, on Brain Response.

ANOVA	Post hoc t-test					MNI Coordinates
Main effect	Direction	Region	Laterality	Cluster size (mm3)	Z score	(x,	y,	z)
Session	PBO>ALC	Middle occipital gyrus	R	10 040	5.40	46	−82	0
			L	504	3.60	−28	−92	6
			L	144	3.50	−38	−72	18
		Cuneus	L	304	4.64	−24	−100	26
			R	720	3.87	20	−94	32
			R	408	3.85	14	−104	18
			R	1232	3.68	2	−92	6
			R	392	3.61	4	−72	12
		Precuneus	L	2392	4.26	−14	−88	48
		Fusiform gyrus	L	8024	4.22	−36	−60	−16
		Superior frontal gyrus/mPFC	R	3000	4.00	8	64	2
			M	856	3.47	0	62	32
		Postcentral gyrus	L	200	3.52	−30	−24	44
		Parahippocampal gyrus	R	112	3.77	22	−44	4
			L	104	3.44	−16	−16	−10
		Gyrus rectus/OFC	R	376	3.74	6	58	−16
		Superior frontal gyrus/OFC	R	544	3.50	2	36	−10
		Cerebellum	R	208	3.63	30	−32	−32
		Posterior cingulate gyrus	L	184	3.49	−14	−36	26
		Inferior frontal gyrus	L	184	3.39	−44	28	4
		Superior occipital gyrus	L	160	3.30	−10	−104	12
	ALC>PBO	Middle frontal gyrus	R	2304	4.65	38	16	50
		Superior frontal gyrus	R	488	3.76	8	28	48
		Postcentral gyrus	R	1432	3.79	60	−30	50
		Cerebellum	L	136	3.65	−10	−44	−18
		Ventral striatuma	L	384	3.63	−18	16	−8
			R	232	3.54	16	16	−6
		Middle temporal gyrus	L	88	3.30	−52	−48	10
Cue	S>C	Middle frontal gyrus/DLPFC	R	680	3.86	36	38	38
			L	616	3.84	−32	38	34
		Anterior cingulate gyrus	R	184	3.59	2	32	6
		Posterior cingulate gyrus	R	152	3.43	8	−30	50
	N>C	Inferior occipital gyrus	R	1336	3.74	26	−96	−6
			L	248	3.26	−26	−98	−16
		Fusiform gyrus	R	344	3.60	28	−36	−22
Interaction	(ALC C & PBO S)>(ALC S & PBO C)	Middle frontal gyrus	L	640	3.99	−20	18	44
		Mid cingulate gyrus	R	1256	3.94	12	−10	42
			R	224	3.55	12	8	36
		Precentral gyrus	R	2968	3.90	26	−28	58
			L	232	3.33	−22	−26	58
		Cerebellum	L	184	3.69	−28	−70	−40
		Putamen	L	104	3.28	−24	0	0

ALC, alcohol; PBO, placebo; S, smoking; C, control; DLPFC, dorsolateral prefrontal cortex; mPFC, medial prefronal cortex; OFC, orbitofrontal cortex; MNI, Montreal Neurologic Institute.

^aA priori region of interest in bold; Significant at p<0.05, false discovery rate (FDR)-corrected for multiple voxel-wise comparisons across the entire brain. All other activations shown at p<0.001 (uncorrected) with a cluster extent threshold of at least 10 contiguous voxels.