Table 1. Main Effects of Session, Cue, and Their Interactions, on Brain Response.
ANOVA | Post hoc t-test |
MNI Coordinates |
||||||
---|---|---|---|---|---|---|---|---|
Main effect | Direction | Region | Laterality | Cluster size (mm3) | Z score | (x, | y, | z) |
Session | PBO>ALC | Middle occipital gyrus | R | 10 040 | 5.40 | 46 | −82 | 0 |
L | 504 | 3.60 | −28 | −92 | 6 | |||
L | 144 | 3.50 | −38 | −72 | 18 | |||
Cuneus | L | 304 | 4.64 | −24 | −100 | 26 | ||
R | 720 | 3.87 | 20 | −94 | 32 | |||
R | 408 | 3.85 | 14 | −104 | 18 | |||
R | 1232 | 3.68 | 2 | −92 | 6 | |||
R | 392 | 3.61 | 4 | −72 | 12 | |||
Precuneus | L | 2392 | 4.26 | −14 | −88 | 48 | ||
Fusiform gyrus | L | 8024 | 4.22 | −36 | −60 | −16 | ||
Superior frontal gyrus/mPFC | R | 3000 | 4.00 | 8 | 64 | 2 | ||
M | 856 | 3.47 | 0 | 62 | 32 | |||
Postcentral gyrus | L | 200 | 3.52 | −30 | −24 | 44 | ||
Parahippocampal gyrus | R | 112 | 3.77 | 22 | −44 | 4 | ||
L | 104 | 3.44 | −16 | −16 | −10 | |||
Gyrus rectus/OFC | R | 376 | 3.74 | 6 | 58 | −16 | ||
Superior frontal gyrus/OFC | R | 544 | 3.50 | 2 | 36 | −10 | ||
Cerebellum | R | 208 | 3.63 | 30 | −32 | −32 | ||
Posterior cingulate gyrus | L | 184 | 3.49 | −14 | −36 | 26 | ||
Inferior frontal gyrus | L | 184 | 3.39 | −44 | 28 | 4 | ||
Superior occipital gyrus | L | 160 | 3.30 | −10 | −104 | 12 | ||
ALC>PBO | Middle frontal gyrus | R | 2304 | 4.65 | 38 | 16 | 50 | |
Superior frontal gyrus | R | 488 | 3.76 | 8 | 28 | 48 | ||
Postcentral gyrus | R | 1432 | 3.79 | 60 | −30 | 50 | ||
Cerebellum | L | 136 | 3.65 | −10 | −44 | −18 | ||
Ventral striatuma | L | 384 | 3.63 | −18 | 16 | −8 | ||
R | 232 | 3.54 | 16 | 16 | −6 | |||
Middle temporal gyrus | L | 88 | 3.30 | −52 | −48 | 10 | ||
Cue | S>C | Middle frontal gyrus/DLPFC | R | 680 | 3.86 | 36 | 38 | 38 |
L | 616 | 3.84 | −32 | 38 | 34 | |||
Anterior cingulate gyrus | R | 184 | 3.59 | 2 | 32 | 6 | ||
Posterior cingulate gyrus | R | 152 | 3.43 | 8 | −30 | 50 | ||
N>C | Inferior occipital gyrus | R | 1336 | 3.74 | 26 | −96 | −6 | |
L | 248 | 3.26 | −26 | −98 | −16 | |||
Fusiform gyrus | R | 344 | 3.60 | 28 | −36 | −22 | ||
Interaction | (ALC C & PBO S)>(ALC S & PBO C) | Middle frontal gyrus | L | 640 | 3.99 | −20 | 18 | 44 |
Mid cingulate gyrus | R | 1256 | 3.94 | 12 | −10 | 42 | ||
R | 224 | 3.55 | 12 | 8 | 36 | |||
Precentral gyrus | R | 2968 | 3.90 | 26 | −28 | 58 | ||
L | 232 | 3.33 | −22 | −26 | 58 | |||
Cerebellum | L | 184 | 3.69 | −28 | −70 | −40 | ||
Putamen | L | 104 | 3.28 | −24 | 0 | 0 |
ALC, alcohol; PBO, placebo; S, smoking; C, control; DLPFC, dorsolateral prefrontal cortex; mPFC, medial prefronal cortex; OFC, orbitofrontal cortex; MNI, Montreal Neurologic Institute.
A priori region of interest in bold; Significant at p<0.05, false discovery rate (FDR)-corrected for multiple voxel-wise comparisons across the entire brain. All other activations shown at p<0.001 (uncorrected) with a cluster extent threshold of at least 10 contiguous voxels.