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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2010 Feb 19;209(2):163–174. doi: 10.1007/s00213-010-1784-0

Fig. 2.

Fig. 2

a C57BL/6J and DBA/2J male mice exhibit a robust difference in head-twitch response to DOI (N=3 mice per dose level per strain). Dose–response profiles show a significant difference in maxima between strains. DBA/2J has approximately 1.5- to twofold greater head-twitch response than C57BL/6J. A 2×8 factorial analysis of variance reveals a significant strain by dose interaction that is resolved into differences between strains at dose levels of 0.4 mg/kg or higher, as indicated by stars. b DOI-induced head-twitch in C57BL/6J and DBA/2J mice is reduced but not eliminated by 5-HT2C antagonist pretreatment, and the strain difference in head-twitch is eradicated by 5-HT2C antagonist pretreatment (N=6 per group). The stars indicate both a significant reduction in head-twitch response after SB206553 or SB242084 pretreatment compared to saline pretreatment, and significant reduction in the difference between strains after 5-HT2C antagonist pretreatment compared to saline (see text for details)