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. Author manuscript; available in PMC: 2010 Aug 15.
Published in final edited form as: J Cell Biochem. 2009 Aug 15;107(6):1222–1236. doi: 10.1002/jcb.22226

Figure 7. Schematic depicting that NFkappaB-mediated cell survival is dependent at least in part on Met.

Figure 7

(A) In the presence of NFkappaB (i.e. p65+/+), cells such as hepatocytes are protected from pro-death signals mediated by the TNF alpha/TNFR-I axis. This is due in part to the upregulated expression of Met tyrosine kinase receptor gene, which encodes a potent pro-survival factor, by NFkappaB, and to lesser extent, by C/EBP beta. (B) In cells lacking NFkappaB (i.e. p65-/-), Met expression, and therefore Met-mediated cytoprotection, are reduced. The pro-apoptotic arm of death signals such as TNF alpha is insufficiently countered, and death pathways prevail.