Figure 6.

Peripheral administration of low-dose leptin does not affect survival after CLP, whereas rescued leptin signaling specifically in CNS is sufficient for normal survival rates in sepsis. a, ob/ob mice with vehicle (via peripheral minipumps, 1 μg/24 h) (n = 10) and ob/ob mice with leptin (peripheral minipumps) (n = 10) underwent CLP and were monitored for survival for 10 d. b, Survival of db/db mice, db/db mice with rescued leptin signaling in CNS neurons, and WT littermates (n = 10–12 per group). Age-matched mice underwent CLP and were monitored for survival until all animals dies. ***p < 0.01 compared with db/db animals.