Table 1.
Description of 560 AMD Cases and 239 Controls
| Clinical Description | AMD Grade | Cases (n) | Controls (n) |
|---|---|---|---|
| No drusen or small (<63 μm), nonextensive drusen without RPE abnormalities | 1 | 0 | 169 |
| Extensive small drusen or nonextensive intermediate drusen (63 μm, 125 μm) and/or RPE hyperpigmentation or hypopigmentation | 2 | 0 | 70 |
| Extensive intermediate drusen or any large soft drusen (125 μm), including drusenoid RPE detachment | 3 | 172 | 0 |
| Geographic atrophy (area of RPE atrophy with sharp margins, usually visible choroidal vessels, at least 175 μm in diameter) | 4 | 75 | 0 |
| Extensive AMD, including nondrusenoid RPE detachment, choroidal neovascularization, subretinal hemorrhage, or fibrosis or photocoagulation scarring consistent with treatment of AMD | 5 | 313 | 0 |
| Total | 560 | 239 | |
| Age at examination, mean y (SD) | 75.5 (8.3) | 66.8 (8.3) | |
| Smoking, % yes, ever | 50 | 41 |