Figure 4.

Inability of MAb F429 to affect the outcome of microbial keratitis in MyD88 knock-out (KO) mice compared to WT C57Bl/6 mice. Upper panels: strain 6294; lower panels: strain 6077. External and internalized levels of indicated P. aeruginosa strain and corneal pathology scores are shown. Points indicate value for an individual mouse (five to eight mice per group), solid lines indicate group medians, and P values between the indicated pairs of data determined from multiple comparison tests. The overall ANOVA P value was <0.002 for all the data sets. Infectious doses: strain 6294: 10⁶ cfu/eye; strain 6077: 1.3 × 10⁶ cfu/eye.