Figure 4.

Decreases in caspase activation and number TUNEL-positive cells correspond to increased long-term survival of photoreceptors. Retinas were detached in the presence of Met12 (50 μg), mMet (50 μg), or vehicle (DMSO), injected into the subretinal space at the time of detachment. Eyes were enucleated after 2 months of detachment, and paraffin sections were stained with 0.5% toluidine blue. (A) Representative photomicrographs. INL, inner nuclear layer; ONL, outer nuclear layer. (B) ONL cell counts normalized to retinal thickness. (C) ONL thickness normalized to retinal thickness. Mean ± SE; n = 3–7.