Table 3.
Downregulated Genes in Areas with Significant RGC Loss in the DBA/2 Retina
| Gene Symbol | RefSeq Accession* | Mod.t | Log2.fd | Gene Name (Affymetrix*) |
|---|---|---|---|---|
| Cul5 | NM_027807 | −14.71 | −1.21 | Cullin 5 |
| Lxn | NM_016753 | −11.36 | −0.66 | Latexin |
| Opa1 | NM_133752 | −10.7 | −0.62 | Optic atrophy 1 homolog (human) |
| Mthfd2 | NM_008638 | −10.6 | −1.14 | Methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase |
| Tatdn1 | NM_175151 | −9.85 | −0.54 | TatD DNase domain containing 1 |
| Sh2bp1 | NM_009431 | −8.61 | −0.53 | SH2 domain binding protein 1 (tetratricopeptide repeat containing) |
| Fzd1 | −8.21 | −0.56 | Frizzled homolog 1 (Drosophila) | |
| Anxa2 | NM_007585 | −8.18 | −0.83 | Annexin A2 |
| Fstl5 | NM_021457 | −7.26 | −0.54 | Follistatin-like 5 |
| Fyttd1 | NM_007585 | −7 | −0.54 | Forty-two-three domain containing 1 |
| Ppp2r5e | NM_012024 | −7 | −0.54 | Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform |
| Zfp318 | NM_021346 | −6.79 | −0.6 | Zinc finger protein 318 |
| Spin2 | NM_001005370 | −6.48 | −0.71 | Spindlin-like |
| Rgs10 | NM_026418 | −6.21 | −0.56 | Regulator of G-protein signalling 10 |
| Egln1 | NM_053207 | −6.17 | −0.54 | EGL nine homolog 1 (C. elegans) |
| Zfp292 | XM_620009 | −6.02 | −1.04 | Zinc finger protein 292 |
| Hdlbp | NM_133808 | −5.96 | −0.89 | High density lipoprotein (HDL) binding protein |
| Acbd3 | NM_133225 | −5.9 | −0.72 | Acyl-Coenzyme A binding domain containing 3 |
| Spock1 | NM_009262 | −5.58 | −0.85 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 |
| Emb | NM_010330 | −5.53 | −0.63 | Embigin |
| Tpmt | NM_016785 | −5.5 | −1.02 | Thiopurine methyltransferase |
| Rgs9 | NM_011268 | −5.46 | −0.57 | Regulator of G-protein signaling 9 |
| Satb1 | NM_009122 | −4.98 | −0.54 | Special AT-rich sequence binding protein 1, mRNA (cDNA clone MGC:18461 IMAGE:4164993) |
| Usp45 | NM_152825 | −4.9 | −0.91 | Ubiquitin-specific peptidase 45 |
| Ociad2 | NM_026950 | −4.9 | −0.52 | OCIA domain containing 2 |
| Kif1b | NM_008441 | −4.84 | −0.78 | Kinesin family member 1 B |
| Pon3 | NM_173006 | −4.8 | −0.5 | Paraoxonase 3 |
| 8430439J12Rik | XM_287445 | −4.76 | −0.67 | RIKEN cDNA 8430439J12 gene |
| C230085N15Rik | — | −4.74 | −0.53 | RIKEN cDNA C230085N15 gene |
| Epb4.112 | NM_013511 | −4.72 | −0.5 | Erythrocyte protein band 4.1-like 2 |
*
See the footnote to Table 1.