Table 5.
Genes Exhibiting Expression Changes (Upregulation or Downregulation) in Areas with RGC Loss in the DBA/2 Retina Compared with Pearl Retina
| Gene Symbol | RefSeq Accession* | Mod.t | Log2.fd | Gene Name (Affymetrix*) |
|---|---|---|---|---|
| Upregulated genes | ||||
| A330076H08Rik | — | 7.80 | 5.11 | RIKEN cDNA A330076H08 gene |
| C3 | NM_009778 | 24.09 | 3.77 | Complement component 3 |
| Cnnm4 | NM_033570 | 4.37 | 3.75 | Cyclin M4 |
| Scnm1 | NM_027013 | 19.17 | 3.63 | Sodium channel modifier 1 |
| Edn2 | NM_007902 | 6.37 | 3.45 | Endothelin 2 |
| Lcn2 | NM_008491 | 11.55 | 3.16 | Lipocalin 2 |
| Ifitm1 | NM_001112715, NM_026820 | 6.33 | 2.95 | Interferon induced transmembrane protein 1 |
| Cacna2d4 | NM_001033382 | 4.95 | 2.93 | Calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
| 4833420D23Rik | — | 9.15 | 2.89 | RIKEN cDNA 4833420D23 gene |
| Tspan7 | NM_019634 | 3.95 | 2.79 | Tetraspanin 7 |
| G6pd2 | NM_008062, NM_019468 | 6.65 | 2.75 | Glucose-6-phosphate Dehydrogenase 2 |
| Ifngr2 | NM_008338 | 4.10 | 2.61 | Interferon gamma receptor 2 |
| Atp1b2 | NM_013415 | 4.25 | 2.60 | ATPase, Na+/K+ transporting, beta 2 polypeptide |
| Steap4 | NM_054098 | 10.00 | 2.58 | STEAP family member 4 |
| Gpbp1 | NM_001122963, NM_028487 | 5.26 | 2.56 | GC-rich promoter binding protein 1 |
| Downregulated genes | ||||
| Kndc1 | NM_177261 | −31.54 | −2.96 | Kinase non-catalytic C-lobe domain (KIND) containing 1 |
| Pou4f2 | NM_138944 | −29.59 | −6.13 | POU domain, class 4, transcription factor 2 |
| BC023969 | — | −25.71 | −3.80 | cDNA sequence BC023969 |
| Tusc5 | NM_177709 | −23.88 | −4.58 | Tumor suppressor candidate 5 |
| Prkaa2 | NM_178143 | −21.91 | −1.77 | Protein kinase, AMP-activated, alpha 2 catalytic subunit |
| Pum2 | NM_030723 | −21.81 | −3.26 | Pumilio 2 (Drosophila) |
| AI506816 | XM_001000526 | −20.90 | −4.65 | Expressed sequence AI506816 |
| Pou4f1 | NM_011143 | −20.38 | −5.08 | POU domain, class 4, transcription factor 1 |
| Plaa | NM_172695 | −20.28 | −1.90 | Phospholipase A2, activating protein |
| Sesn3 | NM_030261 | −20.07 | −2.26 | Sestrin 3 |
| Lrrtm2 | NM_178005 | −19.95 | −3.09 | Leucine rich repeat transmembrane neuronal 2 |
| Nefm | NM_008691 | −19.81 | −3.81 | Neurofilament, medium polypeptide |
| Capn5 | NM_007602 | −16.77 | −1.39 | Calpain 5 |
| Elavl2 | NM_010486, NM_207685, NM_207686 | −16.10 | −2.84 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 |
| Bcl11b | NM_001079883, NM_021399 | −16.08 | −2.07 | B-cell leukemia/lymphoma 11B |
*
See the footnote to Table 1.