Figure 6.

Fusarium keratitis in TLR2^−/− and TLR4^−/− mice. Corneas of C57BL/6, TLR2^−/−, and TLR4^−/− mice were abraded with three parallel scratches and exposed to contact lenses with Fusarium biofilm, as described in the legend to Figure 2. At 24 and 72 hours, the eyes were homogenized and CFUs were assessed. Data points represent individual corneas in two separate experiments. P < 0.001; ANOVA at 24 hours between C57BL/6 and TLR4^−/− mice and between the TLR2^−/− and TLR4^−/− mice and 72-hour data between the C57BL/6 and TLR4^−/− mice.