. 2010 Feb;51(2):844–849. doi: 10.1167/iovs.09-3875

Table 3.

Clinical Features of Normal Subjects and Patients with DE

Group	n	Symptom Severity Score^*	Schirmer 1 Score (mm)	Conjunctival Staining Score^†	Corneal Staining Score^‡	Corneal Subepithelial fibrosis^§	Meibomian Gland Orifice Metaplasia^‖	FCT^¶
Normal	17	11.9 ± 2.3	27.0 ± 7.8	0 ± 0.0	0 ± 0.0	0 ± 0.0	0 ± 0.0	1.5 ± 0.7
All DE	35	34.8 ± 9.4	13.0 ± 11.0	1.7 ± 2.0	4.6 ± 4.4	0.4 ± 0.49	0.47 ± 0.5	4.3 ± 1.0
		P < 0.0001¹	P = 0.0001¹	P < 0.0001¹	P < 0.0001¹			P < 0.0001¹
MGD	20	33.2 ± 8.7	18.5 ± 11.9	0.5 ± 1.01	3.2 ± 2.7	0.47 ± 0.51	0.78 ± 0.41	3.7 ± 2.8
		P < 0.0001¹	P = 0.0001²	P < 0.0001²	P = 0.001³		P < 0.0001^1,2,3	P < 0.0001^a
								P = 0.001²
SS	9	36.8 ± 9.6	4.79 ± 2.0	4.9 ± 2.01	6.33 ± 5.37	0 ± 0	0.2 ± 0.4	5.1 ± 0.8
		P < 0.0001¹	P = 0.0005¹	P < 0.0001¹	P < 0.0001¹			P < 0.0001¹
NK	6	41.2 ± 15.6	8.4 ± 3.0	1.67 ± 2.66	7.93 ± 4.8	0.6 ± 0.4	0 ± 0	3.77 ± 1.7
		P < 0.0001¹	P = 0.0001¹	P < 0.0001¹	P < 0.0001¹			P < 0.0001¹

Normal, normal control group. The mean score of both eyes was used for the Schirmer 1 test, corneal fluorescein staining, conjunctival staining scores and BCVA. P, ¹vs. normal control; ²vs. SS; and ³vs. NK.

Symptom severity score measured by OSDI questionnaire.¹³

^†

Lissamine green staining of the nasal and temporal bulbar conjunctiva was graded 0–3 in each area based on the density of dots.

^‡

Corneal fluorescein staining was graded according to the Baylor grading scheme¹⁴ in each of five zones on a standardized 5-point scale 0 dots, 0; 1–5 dots, 1; 6–15 dots, 2; 16–30 dots, 3; and >30 dots, 4. One point was added to the score if there was one area of confluent staining, and 2 points were added if there were two or more.

^§

0, absent; 1, positive.

^‖

0, absent; 1, positive.

^¶

Tear clearance score was graded from 0 to 6.¹⁵