Table 4.
Clinical Features of Patients with DE Stratified by Severity
| Severity Level | n | Symptom Severity Score* | Schirmer 1 Score (mm) | Conjunctival Staining Score† | Corneal Staining Score‡ | Corneal Subepithelial Fibrosis§ | Meibomian Gland Orifice Metaplasia‖ | FCT¶ |
|---|---|---|---|---|---|---|---|---|
| 1 | 8 | 30.5 ± 11.2 | 18 ± 12 | 0.25 ± 0.46 | 0.75 ± 1 | 0.57 ± 0.53 | 0.71 ± 0.48 | 4.25 ± 1.13 |
| P < 0.0011,4,5 | P < 0.0011 | |||||||
| 2 | 16 | 32.6 ± 10.3 | 14 ± 12 | 1.5 ± 2.3 | 3.6 ± 2 | 0.25 ± 0.44 | 0.62 ± 0.5 | 4.16 ± 1.5 |
| P < 0.0011 | P < 0.0011 | P < 0.001a,d | P < 0.0011 | |||||
| 3 | 7 | 36.3 ± 13.5 | 9 ± 8 | 2.3 ± 2.14 | 9.3 ± 1.5 | 0.7 ± 0.4 | 0.14 ± 0.41 | 3.43 ± 1.66 |
| P < 0.0011 | P < 0.0011,2,3 | |||||||
| 4 | 4 | 41 ± 10.0 | 4.8 ± 1.3 | 5.63 ± 0.75 | 13.7 ± 2.3 | 0.25 ± 0.5 | 0 ± 0 | 5.5 ± 0.41 |
| P < 0.0011 | P < 0.0051,2,3,4 | P < 0.0011,2,4 | P < 0.0011 | |||||
| Control | 17 | 11.9 ± 2.3 | 27.0 ± 7.8 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 1.5 ± 0.7 |
Control, normal control group. The mean score of both eyes was used for the Schirmer 1 test, corneal fluorescein staining. conjunctival staining scores, and BCVA. P, 1vs. control; 2vs. level 1; 3vs. level 2; 4vs. level 3; and 5vs. level 4. Symboled footnotes are described in Table 3.