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. 2010 Feb;51(2):836–843. doi: 10.1167/iovs.09-3937

Scheme 1.

Scheme 1.

2nprop can undergo a base-catalyzed, thermally driven retro-nitroaldol reaction (i.e., reverse Henry) to give formaldehyde and its nitroalkane. Subsequent reaction of formaldehyde with the starting material gives MNPD the nitrodiol. D, deuterium. Adopted from Shvekhgeimer MGA. Rus Chem Rev. 1998;67(1):35–68.